Kidney Regeneration in Mammals
نویسندگان
چکیده
منابع مشابه
Kidney regeneration in mammals.
BACKGROUND Several organs such as the skin and liver have a great capacity for regeneration. However, many approaches only delay the progression of end-stage kidney disease and do not achieve efficient long-term stabilization, let alone regeneration. SUMMARY In mammals, the kidney has an innate but limited capacity for regeneration which can only modify the nephron structure and function but ...
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BACKGROUND Chronic and acute kidney injury damages nephrons, the blood filtering tubules in the kidney. Although mammalian kidneys can regenerate the tubular epithelium of the nephron, no new nephrons are made during adulthood. In contrast, fish are capable of growing nephrons de novo throughout their life. A better understanding of this 'neo-nephrogenic' response in fish may lead to the develo...
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Neonephrogenesis, the capacity to regenerate renal tissue, is a distinctive feature of fish but not usually of mammals. However, evidence exists for kidney repair in response to insulting agents for animals and human beings. Studies have therefore been designed in the past few years to clarify the cellular and molecular basis of renal repair, with the aim to investigate the potential regenerati...
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Despite important progress made in understanding the mechanisms of axon regeneration, how a neuron responds to an injury and makes a regenerative decision remains unclear. In this issue of Genes & Development, Song and colleagues (pp. 1612-1625) investigate axonal and dendritic regeneration in the Drosophila peripheral nervous system (PNS). With some mechanisms shared with mammals, this study r...
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ژورنال
عنوان ژورنال: Nephron Experimental Nephrology
سال: 2014
ISSN: 1660-2129
DOI: 10.1159/000360661